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Muscle Wasting in Obese People
Obese humans lose muscle proteins at a greater rate than their normal-weight counterparts do which makes their skeletal muscles weaker (muscle wasting). Loss of muscle proteins is also age related, starting at middle age and amplified by both obesity and old age.
ZK Muscle Research, a family-based biotech company, discovered that a nontoxic human protein (ZKPr1), delivered either orally or via an injection method, can substantially reduce wasting of muscle proteins and muscle mass in both obese and old normal-weight mice. The company is presently researching the mechanism by which ZKPr1 reduces muscle wasting and the possibility of using this protein as an add-on drug together with GLP-1 based or other weight loss reducing drugs that have no or only small effects on muscle wasting.